Hier entstand in der Vergangenheit immer der Eindruck, dass eingenommenes Zink nur als Unterstützung bei der Aknetherapie zu sehen ist. Habe nun selbst einmal recherschiert und folgende vielversprechende Studien gefunden: [Zinc salts in dermatology] [Article in French] Stephan F, Revuz J. Service de Dermatologie, Hopital Henri Mondor, 51 avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France. Zinc is an essential trace element for the human organism. It acts like cofactor for the metalloenzymes involved in many cellular processes. Its anti-inflammatory activity, which is the basis of therapeutic use, other than acrodermatitis enteropathica, is not well known: production of cytokines, antioxidant activity. Its toxicity is very low, but marked at high doses during chronic administration by the risk of hypocupremia. It is not teratogenic and can be given during pregnancy. Its absorption, through the duodenum, is inhibited by excessive phytate intake. Maximum concentration is reached after 2 to 3 hours. It is widely distributed in the organism, mainly in muscles and bone. Excretion is predominantly digestive. Its spectacular effect in acrodermatitis enteropathica, through compensation of genetically determined malabsorption was discovered in 1973. Its usefulness in acne is based on the anti-inflammatory action and was first described with zinc sulfate, then with better tolerated gluconate. Many controlled studies have shown an efficacy on inflammatory lesions. Doses varied from 30 to 150 mg of elemental zinc and studies against cyclines have shown that minocycline has a superior effect; but zinc might be an alternative treatment when cyclines are contraindicated. To date we don't have convincing data for its use in other indications (leishmaniosis, warts, cutaneous ulcers). Tolerance at usual doses (200 mg of zinc gluconate or 30 mg of elemental zinc) is good. Major side effects are abdominal with nausea, vomiting, but are fleeting and dose dependent. Low doses of zinc gluconate for inflammatory acne. Dreno B, Amblard P, Agache P, Sirot S, Litoux P. 3rd Department of Dermatology, Hotel Dieu, Nantes, France. The effect of zinc on acne is unclear. In this study, only patients with an inflammatory acne were included in a double-blind trial using low doses of zinc gluconate (200 mg/day, corresponding to 30 mg zinc metal). We obtained a significantly different result between zinc and placebo groups in the inflammatory score (p less than 0.02). This efficiency could be explained by the action of zinc on inflammatory cells, especially granulocytes. The effect of oral zinc administration on sebum free fatty acids in acne vulgaris. Rebello T, Atherton DJ, Holden C. Free fatty acids in sebum arise from lipolytic action of bacterial lipases. We have demonstrated an inhibitory effect of zinc on the lipase of the three Propionibacterium species found in human pilosebaceous follicles. We were also able to show a small corresponding fall in the free fatty acid content of skin surface lipid in vivo in acne patients treated with zinc, though this failed to reach statistical significance. Oral zinc sulphate therapy in acne vulgaris: a double-blind trial. Verma KC, Saini AS, Dhamija SK. The effect of zinc sulphate and placebo was compared in a double-blind trial in 56 patients suffering from acne vulgaris. Serum vitamin A levels were studied in all, before and at the end of therapy, 29 patients received zinc sulphate 600 mg daily and 27 patients received placebo. Patients on placebo showed no improvement. After 12 weeks of treatment with zinc sulphate, 17 patients (58%) showed significant improvement. There was a statistically significant decrease in the number of papules, infiltrates and cysts. In zinc-treated cases there was statistically significant increase in serum vitamin A levels, while no change was found in the placebo group. A double-blind trial of a zinc sulphate/citrate complex and tetracycline in the treatment of acne vulgaris. Cunliffe WJ, Burke B, Dodman B, Gould DJ. Forty-eight patients participated in a 3-month double-blind study to compare the effect of orally administered zinc sulphate/citrate complex and tetracycline hydrochloride in acne vulgaris. Tetracycline significantly reduced the overall grade, and the number of non-inflamed lesions, papules and pustules by the third month. It also reduced significantly the non-inflamed lesions and papules at the end of the second month. In contrast, zinc therapy only had a significant effect on the pustules at the third month. The results indicate that tetracycline is far superior to the zinc complex in patients with moderately severe acne. Soweit so gut, 30mg Zinkgluconat sind absolut vertretbar, überdosieren kann man bei der Dosis nicht. Bei mir selbst wirkt Zink im übrigen sehr gut, ich weiss nich warum immer wieder behauptet wird, Zink sei lediglich unterstützend, ich habe schon oft gelesen, dass gerade leichte Fälle mit Hilfe von Zink ihre Akne stark reduzieren konnten.